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apalutamide will minimize the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications that happen to be CYP3A4 substrates may lead to lessen exposure to those drugs.In case you overlook a dose, just take it whe